【陈巍学基因】视频129：系统地比较 11 种空间转录组方法
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解读论文《Systematic comparison of sequencing-based spatial transcriptomic methods》。这篇论文系统地比较 11 种基于高通量测序的空间转录组方法。论文中设定了 3 种标准样品，做了 35 个实验。
从：
1、捕获效率
2、空间分辨率与分子横向扩散
3、数据聚类标注分析
这三个方面来评价这 11 种方法。
被纳入分析评比的方法有：Visium(polyA), Visium(probe), DynaSpatial, Slide-seq, Curio-Bio, Slide-tag, HDST, BMKMANU S1000, Stereo-seq, Salus, PIXEL-seq, DBiT-seq。
参考文献：Yue You, Yuting Fu, et al. Systematic comparison of sequencing-based spatial transcriptomic methods [J] nature methods, 04 July 2024. doi.org/10.1038/s41592-024-02325-3
从：
1、捕获效率
2、空间分辨率与分子横向扩散
3、数据聚类标注分析
这三个方面来评价这 11 种方法。
被纳入分析评比的方法有：Visium(polyA), Visium(probe), DynaSpatial, Slide-seq, Curio-Bio, Slide-tag, HDST, BMKMANU S1000, Stereo-seq, Salus, PIXEL-seq, DBiT-seq。
参考文献：Yue You, Yuting Fu, et al. Systematic comparison of sequencing-based spatial transcriptomic methods [J] nature methods, 04 July 2024. doi.org/10.1038/s41592-024-02325-3
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